AuroGene™ is a new technology for the detection of DNA and RNA on substrate surface using nano-particles. The approach is significantly different from the previous methods of using fluorescent tags or gold nanoparticles with oligonucleotides attached or by using biotin-streptavidin interaction. The AuroGene™ nanoparticles are bind to surface spots where DNA or RNA are located due to electrostatic (e.g., ionic) attraction of the cationic particles and the anionic phosphate groups in the target DNA or RNA backbone. The most important aspect of this detection approach is that no chemical modification of target molecules is required for the detection. The number of hybridized molecules can be quantified by detecting the absorption or light scattered by nanoparticles using a flatbed scanner instead of expensive confocal laser scanners required by conventional fluorescent microarray technologies. The ionic labeling by nanoparticles is fast, simple and sensitive. The method greatly simplifies procedures and reduces the cost of microarray analysis. For additional information please refer to some recent publications:		Ionic attraction of cationic particles by negatively-charged DNA on array surface. DNA on high-density array detected by cationic 250-nm gold particles.
		Y. Sun , K.B. Jacobson, V. Golovlev , “Label-free detection of biomolecules on microarrays using surface-colloid interaction.”, Anal Biochem. 2007 Feb 15;361(2):244-52.
		Y. Sun , W.H. Fan, M.P. McCann, V. Golovlev, “Microarray gene expression analysis free of reverse transcription and dye labeling.”, Anal Biochem. 2005 Oct 15;345(2):312-9.
		V. Golovlev., M.P. McCann., Y. Sun, W.H. Fan., “Microarray Analysis Without Labeling”, American Biotechnology”, American Biotechnology Laboratory,2004 Oct. 22(11) 32.
	Sci-Tec, Inc. Knoxville, TN 2007